PDRN (Salmon DNA)

Your skin has a built-in repair system — Salmon DNA therapy reactivates it. Experience medical-grade PDRN treatment that rebuilds your skin from the inside out, not just on the surface.

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Ready for Salmon DNA Therapy?

If you are seeking a science-backed, non-surgical path to rejuvenation, our Salmon DNA PDRN Therapy is designed specifically for you. Achieve subtle, sophisticated results that evolve with your skin’s biological rhythm, with visible improvements typically beginning within 2–3 weeks.

A concentrated drop of PDRN extract highlighting the cellular repair benefits of Salmon DNA

What Is PDRN (Salmon DNA)?

PDRN (Polydeoxyribonucleotide) is a highly purified bioactive extract derived from Salmon DNA. Structurally compatible with human DNA, it delivers nucleotide fragments that damaged skin cells use to rebuild and regenerate — functioning as a molecular repair kit for the dermis.

Unlike traditional skin boosters that hydrate passively, PDRN works at the source. It activates the A2A adenosine receptor pathway, stimulating fibroblast proliferation, promoting the synthesis of new collagen and elastin, and suppressing pro-inflammatory signals. The result is a measurable improvement in skin architecture — not a temporary surface correction.

Key benefits of Salmon DNA Therapy

  1. Stimulates fibroblast activity and new collagen formation
  2. Reduces post-acne marks and refines skin texture
  3. Strengthens the epidermal barrier and hydration retention
  4. Calms chronic inflammation, redness, and sensitivity
  5. Supports healing after laser, chemical peel, or microneedling procedures

Targeted Concerns: Is Salmon DNA Therapy Right for You?

Salmon DNA (PDRN) therapy is best suited for skin that needs regeneration — not just surface hydration. At Skincare Sommelier Beauty Lab & Med Spa in Forest Hills, your aesthetic director conducts a thorough skin assessment before recommending any protocol.

The ideal candidate for PDRN (Salmon DNA) Therapy

  • Post-acne scarring and persistent hyperpigmentation unresolved by topical products
  • Loss of skin firmness and dermal thinning in the cheeks, under-eye area, or jawline
  • Dull, uneven tone from prolonged urban exposure — what our Forest Hills clients call “NYC city skin”.
  • Chronic redness, rosacea-prone reactivity, or a compromised skin barrier
  • Pre- or post-procedure skin: preparing before laser resurfacing or accelerating recovery afterward
  • Sensitivity to traditional dermal fillers, or a preference for a biocompatible, non-volumizing alternative

Sommelier Team, says,

“When we assess a new client, we evaluating what the skin has lost at the structural level. Salmon DNA therapy is our go-to for patients whose skin needs to rebuild from within, where fillers would be premature, and topicals have already reached their ceiling. It’s regenerative aesthetics in the truest sense.”

How Salmon DNA Works — Step by Step

Every session follows a medically structured protocol. Here is exactly what to expect — from your first conversation with us to the moment you walk out the door.

Consultation

We review your skin history, current concerns, and goals. Professional diagnostics assess dermal density, pigmentation, and barrier integrity. Your PDRN concentration and delivery method are selected based on your specific case.

Preparation

The treatment area is cleansed, and a medical-grade topical anesthetic is applied for 20 minutes. All instruments are single-use. Our treatment room maintains clinical sterility standards at all times.

Treatment (30–45 min)

PDRN is delivered via microinjections (mesotherapy) or combined with microneedling to achieve deeper dermal penetration. Both methods ensure uniform distribution across the target zones. Most clients describe only mild pressure — no significant discomfort.

Recovery

Expect minor redness and micro-swelling at injection sites, which should resolve within 12–24 hours. No bandaging, no required downtime. Avoid direct sun and intense exercise for 24 hours. You’re otherwise free to go about your day.

Results timeline

Initial improvements in texture and radiance appear within 2–3 weeks. Optimal results develop after a full course of 3–4 sessions, spaced 2–4 weeks apart. Collagen remodeling continues for up to 3-6 months post-treatment.

Aesthetician applying PDRN Salmon DNA serum to a patient's face during a skin remodeling treatment

Advanced Combinations of PDRN: Amplifying Your Results

Salmon DNA PDRN integrates seamlessly with other treatments when a single modality is not enough. These are the combinations we use most often — and why they work.

  1. Salmon DNA + Microneedling. Mechanical collagen induction meets biological repair. Micro-channels created by needling drive PDRN deeper into the dermis, amplifying uptake. In our clinical experience, clients with post-acne scarring or significant texture irregularities see measurably greater improvement with this combination than with either modality alone.
  2. Salmon DNA + Dermal Fillers. Fillers restore volume; PDRN improves the quality of the surrounding tissue. The combination reduces the risk of textural irregularities and supports long-term filler integration.
  3. Salmon DNA as Pre-Laser Preparation. Applied 2–3 weeks before ablative laser treatments, PDRN strengthens the skin barrier and primes the repair cascade — for most clients, resulting in noticeably faster recovery and reduced post-inflammatory redness.
YOUR BEAUTY JOURNEY STARTS HERE

Why Choose Skincare Sommelier Beauty Lab & Med Spa for PDRN (Salmon DNA)?

Our clients in Forest Hills, Queens, are not looking for dramatic transformations. They want precision – results that are visible without being obvious. We built our practice around exactly that standard, and every aspect of how we deliver PDRN (Salmon DNA) therapy reflects it.

“I see too many clients who have been told they need volume when what their skin actually needs is quality. PDRN changed how I approach regenerative care — it gave us a tool that works with the skin’s own biology instead of overriding it. After a full Salmon DNA course, clients look like the best version of themselves.”

The Sommelier Team

What Our Clients Are Saying

Our clients love their experiences at Skincare Sommelier Beauty Lab & Med Spa. Here’s what they have to say:

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5.0
Based on 90 reviews
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Lia Wetter profile picture
Lia Wetter
15:45 08 May 26
Amazing !!! The girls are the best, always so kind and happy to answer all your questions. The place is cute and clean !! Not even 1 min walking from the subway station. I definitely recommend this place to do your laser I love it !!
Katherine Gil profile picture
Katherine Gil
04:02 25 Apr 26
Karina was very knowledgeable and honest and did amazing work! The space was clean, beautiful and very relaxing . Can’t wait until my next visit !
Miguel Ramos profile picture
Miguel Ramos
18:06 23 Apr 26
Did full body laser hair removal including intimate laser. Way easier than I thought, basically painless and you can feel the cooling which helps a lot. Halyna laser tech was great, professional quick and thorough. Place is clean. 4 sessions in and already seeing results. I have a higher skin tone too and it’s been completely safe. Would recommend.
Devika Sookbir profile picture
Devika Sookbir
20:32 18 Apr 26
Very friendly staff, service is excellent, skin feels great and will always choose skincare sommelier beauty lad and med spa…
Jacklynn Katz profile picture
Jacklynn Katz
20:27 18 Apr 26
I did 3 sessions of microneedling with Karina and I am happy with the results. The package was affordable and the place is very nice and clean. I will definitely come back to do more sessions. Karina is thorough and transparent about results. I recommend this place for facials and other services.
Hailey Q. Molina profile picture
Hailey Q. Molina
18:14 17 Feb 26
I had the best experience with Halyna for laser hair removal! From the very beginning, she made me feel so comfortable and explained the entire process in detail. She’s extremely professional, gentle, and knowledgeable. The treatment was quick and way less painful than I expected.

After just a few sessions, I’ve already noticed such a big difference — slower growth and smoother skin. Her space is clean, welcoming, and very calming. You can tell she truly cares about her clients and their results.

I highly recommend Halyna to anyone considering laser hair removal. She’s amazing at what she does and makes the whole experience easy and stress-free! ✨
Amanda Lee profile picture
Amanda Lee
18:38 14 Feb 26
Tried microneedling for the first time and Karina made it such a great experience! She explained everything she was doing, what products were being used and checked in on how I was feeling at all the right times. She’s basically a human dictionary of helpful knowledge and once she was familiar with my skin, was spot-on at recognizing what I needed straight away. I’m always so comfortable getting treatments from her knowing that my skin is in such great hands! Did a facial massage with her too that was so relaxing and helped reduce a lot of inflammation. I have no doubt that Karina’s thoughtfulness, professionalism and energy is part of what makes visiting Skincare Sommelier such a wonderful experience every time. I would highly recommend the microneedling treatment and facial massages, and I’m definitely going to returning to try other treatments!
Maria Elekidou profile picture
Maria Elekidou
01:28 14 Feb 26
I had a fantastic facial experience with Karina—she was incredibly attentive to my skin’s needs. From the start, she was honest and took the time to explain the right skincare routine and products for my very dehydrated skin. Just one day later, my skin is glowing and dewy. I can’t recommend her services enough, and the price is very reasonable for the quality you receive. Thank you and I can't wait to be back!
Christina Billi profile picture
Christina Billi
21:55 12 Dec 25
Ive been going to Irina for my lips when she was located in Jersey, so of course i made the trip to see her at this new location for a touch up on my lips!! This place was so cute with chic decor, very clean & everyone was SO NICE. I was taken care of right away by the woman at the front desk (she was so sweet) & the irina blessed me again with beautiful lips😍🥰✨ her technique & attention to detail is insane. She is so talented & I cant wait to make the trip again! 🫶🏼 Also, very reasonable pricing for the work you’re getting. I loved my whole experience.
Christine Chery profile picture
Christine Chery
01:46 11 Dec 25
I walked into Skin Care Sommelier a year ago out of pure curiosity, but also with deep unhappiness about what had happened to my face over the previous five years. My skin had started looking sunken, dull, and lacking vibrancy. In my early 40s, I wasn't ready for aging to show up this way.

Karina and Irene have been absolutely amazing. From day one, they've made me feel completely at home. They're warm, inviting, and genuinely funny—they know exactly how to calm me down when I'm nervous. I've even worked from their office while my face is being numbed! They never push anything on me—just thoughtful suggestions that have left me truly happy with what I see in the mirror.

I've done everything from Sculptra to the most incredible facials (I literally pass out during them, they're so relaxing). Most recently, I got Radiesse and an amazing microneedling treatment with Sylfirm X, the first FDA-approved microneedling device, to treat my melasma and tighten my skin. As promised, this treatment left me with no redness, and other than the fact that I could already see the skin around my neck had tightened and my skin absolutely glowing, you couldn't tell at all that I'd had anything done.

A year later, I couldn't be happier with my results and the care I've received. Highly recommend!

Join our growing family of satisfied clients and let us help you achieve your beauty and wellness goals.

FAQ about PDRN (Salmon DNA)

Salmon DNA PDRN is highly purified to remove proteins, making it biocompatible with minimal allergy risk. Clients with known fish or seafood allergies receive a skin sensitivity test before treatment. Please disclose any allergies at your consultation.

A standard course is 3–4 sessions, spaced 2–4 weeks apart. Many clients notice improved radiance and texture after the first session; full structural results – including scar remodeling and dermal density gains – develop over the full course and continue to build for up to 3 months.

Minimal. Mild redness and micro-swelling at injection sites typically resolve within 12–24 hours. Avoid direct sun, saunas, and intense exercise for 24 hours. Otherwise, your schedule is unaffected.

Hyaluronic acid skinboosters hydrate by attracting water into the dermis — a surface-level effect. Salmon DNA PDRN activates cellular repair pathways, stimulating the production of new collagen and elastin and reducing chronic inflammation. The two approaches address different problems and can be used together.

Fillers add volume. Salmon DNA improves tissue quality without altering facial structure. For clients who want to avoid migration risk or an “overdone” appearance, PDRN is a biocompatible alternative that produces natural-looking improvements in texture, tone, and elasticity.

Yes — it is one of PDRN’s strongest clinical applications. Applied after ablative or non-ablative procedures, it accelerates epidermal recovery and reduces post-inflammatory redness. It is also used pre-treatment to prime the skin’s repair capacity. Your aesthetic director will advise on timing.

Face (cheeks, perioral area, under-eye, forehead), neck, décolletage, and hands. All areas where dermal thinning and photoaging are pronounced but frequently undertreated.

After a complete course, results typically last 6–12 months, depending on age, skin condition, and lifestyle. Annual maintenance sessions are recommended to sustain collagen levels and tissue quality.

Discomfort is minimal. A medical-grade topical anesthetic is applied before treatment. Most clients describe mild pressure or brief warmth — not pain. Fine-gauge needles are selected specifically for patient comfort.

Yes. Polydeoxyribonucleotide is the scientific name for PDRN. You may also see it called Rejuran (a branded Korean formulation), PN therapy, or Salmon DNA therapy. All refer to the same class of bioactive molecules. At Skincare Sommelier, we use pharmaceutical-grade formulations selected for purity and clinical evidence.

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